| Round 1 | Team | Pick | |
| 1 | Arizona Cardinals | Kyler Murray (Oklahoma) | QB |
| 2 | San Francisco 49ers | Nick Bosa (OSU) | EDGE |
| 3 | New York Jets | Quinnen Williams (Alabama) | DL |
| 4 | Oakland Raiders | Devin White (LSU) | LB |
| 5 | Tampa Bay Bucs | Ed Oliver (Houston) | DL |
| 6 | New York Giants | Josh Allen (Kentucky) | EDGE |
| 7 | Jacksonville Jaguars | Jawaan Taylor (Florida) | OL |
| 8 | Detroit Lions | Devin Bush (Michigan) | LB |
| 9 | Buffalo Bills | Jonah Williams (Alabama) | OL |
| 10 | Denver Broncos | T.J. Hockenson (Iowa) | TE |
| 11 | Cincinnati Bengals | Dwayne Haskins (OSU) | QB |
| 12 | Green Bay Packers | Marquise Brown (Oklahoma) | WR |
| 13 | Miami Dolphins | Christian Wilkins (Clemson) | DL |
| 14 | Atlanta Falcons | Montez Sweat (Miss St.) | EDGE |
| 15 | Washington Redskins | D.K. Metcalf (Ole Miss) | WR |
| 16 | Carolina Panthers | Brian Burns (FSU) | EDGE |
| 17 | New York Giants | Daniel Jones (Duke) | QB |
| 18 | Minnesota Vikings | Andre Dillard (Wash St.) | OL |
| 19 | Tennessee Titans | Rashan Gary (Michigan) | EDGE |
| 20 | Pittsburgh Steelers | Rock Ya-Sin (Temple) | CB |
| 21 | Seattle Seahawks | Clelin Ferrell (Clemson) | EDGE |
| 22 | Baltimore Ravens | Garrett Bradbury (NC State) | OL |
| 23 | Houston Texans | Cody Ford (Oklahoma) | OL |
| 24 | Oakland Raiders | Josh Jacobs (Alabama) | RB |
| 25 | Philadelphia Eagles | Chris Lindstrom (BC) | OL |
| 26 | Indianapolis Colts | Jerry Tillery (Notre Dame) | DL |
| 27 | Oakland Raiders | Byron Murphy (Washington) | CB |
| 28 | L.A. Chargers | Hakeem Butler (Iowa St) | WR |
| 29 | Seattle Seahawks | Juan Thorngood (Virginia) | S |
| 30 | Green Bay Packers | Chauncey Gardner-Johnson (Florida) | S |
| 31 | L.A. Rams | Dexter Lawrence (Clemson) | DL |
| 32 | New England Patriots | Chase Winovich (Michigan) | EDGE |